Capsella bursa-pastoris L. Medick ("Chichicara") is traditionally used in the Peruvian Andes for gastric disorders. This study evaluated the phytochemical profile and antioxidant activity of different polarity fractions. The ethanolic extract (reflux, yield 10%) was partitioned into petroleum ether, dichloromethane, ethyl acetate, and aqueous fractions. Phytochemical screening using standard color tests revealed flavonoids, tannins, alkaloids, triterpenes/steroids, catechins, and saponins. Antioxidant activity was evaluated by DPPH (IC₅₀), ABTS (TEAC), and FRAP assays. Total phenolics were quantified by the Folin-Ciocalteu method. The ethyl acetate fraction showed the highest DPPH radical scavenging activity (IC₅₀ = 1.37 mg/mL). The same fraction showed the highest ABTS activity (TEAC = 9.336 meq Trolox at 10 mg/mL). The petroleum ether fraction exhibited the highest FRAP activity (TEAC = 2.801 meq Trolox). Total phenolic content was also highest in the ethyl acetate fraction (0.398 mg GAE at 0.125 mg/mL). In conclusion, Capsella bursa-pastoris contains diverse antioxidants with multiple mechanisms of action. This validates its traditional use for gastric disorders. The ethyl acetate fraction is the most promising source of radical scavengers. Further isolation of active compounds and in vivo studies are recommended.