Garlic (Allium sativum) and honey are widely recognized natural products with diverse therapeutic potentials attributed to their rich phytochemical composition and distinctive physicochemical properties. This study aimed to evaluate the physicochemical characteristics, phytochemical profile, and chemical composition of garlic, honey, and their combined extracts, with particular emphasis on elucidating the bioactive constituents responsible for their potential therapeutic applications. Standard analytical procedures were employed to determine key physicochemical parameters, including pH, acidity, and ash content, while qualitative and quantitative phytochemical analyses were conducted to identify and quantify major bioactive compounds such as phenolics and alkaloids. High-Performance Liquid Chromatography (HPLC) was utilized to characterize the chemical constituents of the garlic–honey extract. The results revealed notable variations in physicochemical properties among the samples, with the combined extract, particularly the ethanolic garlic–honey extract, exhibiting enhanced acidity and a profile suggestive of improved bioavailability and stability. Phytochemical screening confirmed the presence of reducing sugars, alkaloids, flavonoids, tannins, saponins, and phenolic compounds across all samples, with significantly higher total phenolic and alkaloid contents observed in the combined extracts. HPLC analysis further identified key bioactive compounds, including allicin, diallyl trisulfide, caffeic acid, and diallyl disulfide, indicating a synergistically enriched phytochemical composition. The integration of garlic and honey resulted in a composite extract with improved chemical complexity and enhanced concentration of pharmacologically relevant compounds. These findings suggest that the synergistic combination of these natural products may potentiate their functional and therapeutic properties, thereby supporting their application in nutraceutical development and complementary medicine. The study provides a biochemical basis for the utilization of garlic–honey formulations and highlights the importance of extraction methods in optimizing bioactive compound yield.